Sunday, June 5, 2011

Where To Get Prilosec Coupons Printable?

Prilosec is an effective medicine that treats heartburn caused by too much stomach acid. It prevents production of stomach acid. Heartburn is a serious condition that may cause a burning pain in your chest. This is why you need to Buy Prilosec coupon at reduced price. The chest sensational pain can prevent you from enjoying your daily activities.

Prilosec is the only effective medicine that prevents such cases. It gives you a quicker relief to make live a healthy life. Price is always a major challenge to many people who suffer from heartburn conditions. Good news is that you can now buy this medicine at a much-reduced price. Here are some advantages of prilosec heartburn relief:
  • This powerful drug offers faster heartburn relief. It works very effectively and you get a better feeling after a short time.
  • Prilosec coupons save you much money. It enables you to buy at a very affordable price. You can visit internet and get these coupons so that you save money.
  • It is the most effective medicine worldwide. Top doctors also recommend its use. It has solutions to all your heartburn problems. This means within a short time, you are able to go back to your normal lifestyle.
You can also find prilosec coupons printable in newspapers or online. It is time to let everyone live a healthy life free from pains. The best way to ensure this is through affordable prilosec. Living a life free from any pain enables you to be independent in life. This is because you can enjoy work without feeling any pain. Internet is the best place where you can get a variety of drug coupons. Internet is also the fastest way to buy medicine.

You do not spend any transportation cost when you buy online. It allows you to get everything you want at your comfort zone. You can print these coupons and shop whenever you feel like. It lets you save money when you are buying prilosec at any shop or drug manufacturing company.

Such coupons show how much money you can save when you buy this heartburn relief medicine. Pain is the most discomfort feeling that can make you run mad. The good thing is that most of these cases are preventable. Just find prilosec coupons printable online and buy at reduced price. It is high time that you do not have to put up with unnecessary pain.

Tuesday, September 22, 2009

Medication Treatment of Gastroesophageal Reflux Disease (GERD)

Over-the-counter medication is the first line treatment of GERD is with over the counter antacids like aluminum hydroxide (Amphojel, Maalox) or magnesium combinations include Phillips' Milk of Magnesia, Gaviscon and Riopan. Aluminum can cause constipation, and magnesium diarrhea. These compounds work by coating the stomach and provide protection against the corrosive effects of stomach acid. Ulcers need more aggressive treatment, since bleeding from ulcers can be life threatening.

The original medications for the treatment of both GERD and ulcers were the histamine-2 (H2) blockers, like cimetidine (Tagamet), Ranitidine (Zantac) and famotidine (Pepcid). These worked by decreasing the amount of acid in the stomach, which promotes healing of ulcers and reduces gastric reflux. Patients with reduced kidney or liver function can develop confusion with H2 blockers. Side effects include diarrhea, dizziness, nausea, and headache. Tagamet can impair sexual function.

In 1998 AstraZenica introduced Prilosec (omeprazole), the first of a new class of medications for GERD called Proton Pump Inhibitors (PPI). PPIs on the market include lansoprazole (Prevacid), pantoprazole (Protonix), rabeprozale (Aciphex), esomeprazole (Nexium), and omeprazole (Prilosec). They act by blocking the H+ (hydrogen) K+ (potassium) ATPase pump in the stomach, which has the effect of decreasing acid secretion in the stomach. The PPIs have been shown to be more effective than placebo in promoting the healing of ulcers and decreasing symptoms of GERD. PPIs lead to a 33% improvement in ulcer healing compared to the older H2 blocker medication, ranitidine. The PPIs decrease acid secretion to a greater degree than H2 blockers, and are more effective in treatment, although they cost more than the older drugs because they are only available by prescription.

PPIs have a low side effect profile, with side effects in less than 5% of patients. The most common side effects are headache, diarrhea, stomach pain, fever, sore throat, and nausea. The diarrhea may be related to suppression of acid formation, which alters the natural bacteria content of the gut. Overall PPIs are fairly safe.

A review of 21 randomised controlled trials of PPIs in patients with proven peptic ulcers showed no effect on mortality, but a reduction in re-bleeding and repeat surgery of about 50%.

There is no evidence that any of the PPIs are superior to one another in efficacy or safety. Since omeprazole (Prilosec) is now available as a generic, it is the cheapest, and therefore recommended PPI.

You have probably seen the man on TV talking about the "purple pill" or Nexium (Esomeprazole magnesium). This particular purple pill is a replacement of the original purple pill, Prilosec. Both should probably be called the green pill because of all the money they have made and continue to make for the manufacturer, AstraZenica. They are both widely popular and equally effective medications. After its introduction in 1998, sales of Prilosec continued to rise year after year until it reached sales of one billion dollars a year in 1995 and peaked at 4 billion dollars a year in 2000 when it was the most popular drug in the world, as reported by National Public Radio (April 18, 2002).

In 2002 AstraZenica convened a team to assess the impact of their blockbuster Prilosec going off patent. In response to the potential revenue loss that generics would cause, they decided to take a variation of the drug (a metabolite) and put it on patent, and then marketed the new version as an improvement on the original. You see, all molecules come in one version, and an identical version that is a "mirror version" (i.e. if you held it up to a mirror it would look the same). In the case of Prilosec, it was a mixture of left and right, but it turned out that the left hand variety worked better. So the company took the left hand version and called it Nexium; they tested a higher dose of the "new" drug against the "old" drug to "prove" that it was better, and sent out an army of sales people to convince doctors that this was the case. Needless to say if you took higher doses of the older Prilosec you would get a regular dose of Nexium, the "purple pill." It was an effective campaign: by 2002 the company had weaned one in six former Prilosec users off of Prilosec and onto Nexium. At $1,500 a year it is much more expensive than the generic versions of Prilosec ($150/year). Why not just take higher doses of Prilosec - it will eventually get your Nexium fix for a lot less money.

Osteoporosis, Heartburn And Celiac Disease: Is A Gluten-Free Diet Safer Than Prilosec For Reflux

Osteoporosis may be increased by acid reflux medications: Osteoporosis is increased by long-term use of acid blocker medications called proton pump inhibitors (PPI’s), like nexium, prilosec, and Prevacid according to a new study. These PPI medications consistently are at the top of the list of most commonly prescribed drugs. Prilosec OTC is also available without a prescription. When heartburn, the primary symptom of acid reflux, is chronic doctors usually prescribe PPI’s like Nexium.

Heartburn is a common unrecognized symptom of celiac disease:
Most doctors are unaware that heartburn is a common symptom of undiagnosed celiac disease. Most are also unaware that osteoporosis is a common complication of this disorder. As a result, medications that may cause or worsen osteoporosis are being given to or taken by people who have heartburn due to unrecognized CD. The result is that the misdiagnosis of the root cause of the problem leads to treatment that may also be causing or worsening osteoporosis.

Osteoporosis, though it increases with age, occurs earlier in bowel diseases:
The prevalence is less than 15% at age 50 but increases to almost 30% at age 60, 50% at age 70 and 70% at age 80. As a practicing gastroenterologist I have noted an increasing number of below 60-year-old women and many more men who have been diagnosed with osteoporosis who have never been screened for celiac disease or inflammatory bowel disease, both intestinal conditions commonly associated with an increase risk of osteoporosis.

Few doctors are aware that osteoporosis and heartburn are associated with celiac:
One study has highlighted the unawareness of primary care doctors that osteoporosis is associated with celiac disease. A large survey documented that less than half of doctors are aware that osteoporosis is a manifestation of celiac disease. Heartburn is also a common symptom also not commonly recognized by doctors as a manifestation of celiac disease. Gluten ingestion can impair gastric emptying resulting in more gastro-esophageal reflux. Initiation of a gluten-free diet has been shown to diminish reflux symptoms and result in the healing of esophagitis.

Reflux symptoms respond to a gluten-free diet:
Several patients I have evaluated for reflux symptoms, particularly when these symptoms were poorly controlled or the patient was considering surgery rather than take daily medications, were found to have celiac disease or non-celiac gluten sensitivity. In my experience, reflux symptoms frequently dramatically improve on a gluten free diet.

The positive effect of a gluten-free diet in relieving heartburn is not limited to celiac disease:
The beneficial effect of a gluten-free diet has been observed not only in celiac disease patients but also in those not meeting strict diagnostic criteria for CD. Prior to starting a gluten-free diet I took a daily proton pump inhibitor myself. After a GFD, I occasionally experience heartburn when I drink too much coffee or combine coffee, alcohol and chocolate in the same meal. In my opinion, everyone with significant heartburn or a diagnosis of reflux disease should be screened for gluten sensitivity and/or consider a trial of GFD.

How much does celiac disease increase the risk of osteoporosis?
How much celiac disease increases osteoporosis is debated. Studies have shown from small increases (1.5-1.8 times) to much larger (3-5 times) increases of osteoporosis in CD. Such increased risk has prompted for calls for screening all people with celiac disease for osteoporosis and all people with osteoporosis for celiac disease.

Increased risk of osteoporosis raises concern about long-term use of acid blocking medication:
With this new study raising the concern about long-term use of acid blocking medications causing an increase risk of osteoporosis and the frequently unrecognized association of heartburn with undiagnosed celiac disease the use of these medications without excluding CD and considering this side effect is dangerous. Do not blindly accept a doctor’s offer to write you a prescription for acid blocker medications without looking further into the possible causes of your heartburn as well as the risks of simply treating your symptom with a medication that may actually be worsening the complication risks of an underlying undiagnosed problem that can be simply treated by diet.